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Oligodendrocytes

Oligodendrocytes (from Greek, meaning 'cells with a few branches'), or oligodendroglia, are a type of neuroglia whose main functions are to provide support and insulation to axons in the central nervous system of some vertebrates, equivalent to the function performed by Schwann cells in the peripheral nervous system. Oligodendrocytes do this by creating the myelin sheath, which is 80% lipid and 20% protein. A single oligodendrocyte can extend its processes to 50 axons, wrapping approximately 1 μm of myelin sheath around each axon; Schwann cells, on the other hand, can wrap around only one axon. Each oligodendrocyte forms one segment of myelin for several adjacent axons.


Oligodendrocytes are found only in the central nervous system, which comprises the brain and spinal cord. These cells were originally thought to have been produced in the ventral neural tube; however, research now shows oligodendrocytes originate from the ventral ventricular zone of the embryonic spinal cord and possibly have some concentrations in the forebrain. They are the last cell type to be generated in the CNS.

Oligodendrocytes in rat cerebellum stained with antibody to myelin basic protein in red and for DNA in blue. Two oligodendrocyte cell bodies are clearly visible as well as several myelinated axons. These are hollow tubes and so appear as "tramlines" in this confocal image. Most of the DNA is in the nuclei of cerebellum granule cells, which are small interneurons.

The Oligodendrocytes markers are: OligodendrocytesO4 Antibody, Olig2 Antibody, NG2 Antibody, SOX10 Antibody, Myelin basic protein Antibody

Cat. No

Antigen

Host

Clone

Isotype

Applications

Format

Species

Q.ty

AB-82516

Myelin basic protein

Rb

POLY

IgG

WB , IHC(P), IF

Serum

Hu, Ms, Rat

100 ul

MAB-10660

Myelin basic protein

Ms

7D2

IgG1k

ICC IF, IHC, WB

Purified

Hu, Ms, Rt, Ct, Ch

100 ug

MAB-94229

Myelin basic protein

Ms

7G7

IgG1

WB, IF, ICC, IHC

Purified

Hu, Rt, Ms, Cw, Pg, Ho

100 ug

AB-83751

Myelin basic protein

Ch

POLY

IgG

WB, IF/ICC, IHC

Purified

Hu, Rt, Ms, Cw, Pg, Ho

100 ug

AB-80517

NG2

Rb

POLY

IgG

WB, IF

Aff. Pur.

Hu, Ms, Rt

100 ug

AB-82259

Olig 1

Rb

POLY

IgG

WB

Aff. Pur.

Hu

100 ug

AB-J1955

Olig 1

Rb

POLY

IgG

WB, ELISA

Aff. Pur.

100 μl

MAB-90959

Olig 2

Ms

1G11

IgG1

FC,IF,WB,IHC(P),ICC

Ascites

Hu

100 ul

AB-10688

Olig 2

Rb

POLY

IgG

WB, IHC(P)

Purified

Hu, Ms, Rt

100 ul

AB-10379

Olig 3

Rb

POLY

IgG

WB

Aff. Pur.

Ms,Rt

100 ug

AB-J1956

Olig 3

Rb

POLY

IgG

WB, ELISA

Aff. Pur.

100 μl

MAB-11058

Oligodendrocytes O1

Ms

O1

IgM

IHC, ICC

Purified

Rt, Hu, Ms, Ch

50 ug

MAB-10259

Oligodendrocytes O4

Ms

81

IgM

IHC, ICC

Purified

Hu, Ms, Rt, Ch

50 ug

MAB-345-50

Oligodendrocytes O4

Ms

81

IgM

IHC, ICC

Purified

Hu, Ms, Rt, Ch

50 ug

AB-10868

SOX10

Rb

POLY

IgG

WB, IHC(P)

Aff. Pur.

Hu,Ms,Rt

100 ug

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