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Schwann Cells

Schwann cells or neurolemmocytes are the principal glia of the peripheral nervous system (PNS). Glial cells function to support neurons and in the PNS, also include satellite cells, olfactory ensheathing cells, enteric glia and glia that reside at sensory nerve endings, such as the Pacinian corpuscle. The two types of Schwann cells are myelinating and nonmyelinating. Myelinating Schwann cells wrap around axons of motor and sensory neurons to form the myelin sheath. The Schwann cell promoter is present in the downstream region of the human dystrophin gene that gives shortened transcript that are again synthesized in a tissue-specific manner.

During the development of the PNS, the regulatory mechanisms of myelination are controlled by feedforward interaction of specific genes, influencing transcriptional cascades and shaping the morphology of the myelinated nerve fibers.

Schwann cells are involved in many important aspects of peripheral nerve biology—the conduction of nervous impulses along axons, nerve development and regeneration, trophic support for neurons, production of the nerve extracellular matrix, modulation of neuromuscular synaptic activity, and presentation of antigens to T-lymphocytes.

They are named after physiologist Theodor Schwann.

Charcot–Marie–Tooth disease, Guillain–Barré syndrome (acute inflammatory demyelinating polyradiculopathy type), schwannomatosis, chronic inflammatory demyelinating polyneuropathy, and leprosy are all neuropathies involving Schwann cells.

The PNS has satellite cells and Schwann cells.

A Schwann cell in culture

The Schwann cells markers are: GAP43 Antibody, NCAM/CD56 Antibody, S-100 A Antibody, S-100 Beta Antibody

Cat. No

Antigen

Host

Clone

Isotype

Applications

Format

Species

Q.ty

MAB-94087

GAP43

Ms

1E3

IgG1

WB, ICC, IF, IHC

Purified

Hu, Ho,Cw, Pg, Ch, Rt, Ms

100 ug

AB-82460

GAP43

Rb

POLY

IgG

WB, ICC, IF, IHC

Purified

Hu, Ho,Cw, Pg, Ch, Rt, Ms

100 ug

AB-83908

GAP43

Ch

POLY

IgY

WB, IF, IHC

Purified

Hu Rt Ms,Cw, Pg, Ho, Ch,

100 ug

MAB-10060

NCAM

Ms

MEM-188

IgG2a

FC, IP, IHC(P)

Purified

Hu

100 ug

AB-83574

NCAM

Rb

POLY

IgG

WB, IHC(P)

Aff. Pur.

Hu, Ms,Rt

100μg

MAB-94104

S-100 A

Ms

217

IgG1k

IHC (P), IHC(F) , ICC, IF

Purified

Hu, Ms, Rt, Bv, Mk

100 ug

AB-82413

S-100 A

Rb

POLY

IgG

IHC (P), IHC(F) , ICC, IF

Aff. Pur.

Hu, Ms, Rt, Bv, Mk

100 ug

MAB-94283

S-100 beta

Rb

S100B

IgG

WB, ICC, IHC (P), IF, IP

Aff. Pur.

Hu, Ms, Rat

100 ug

MAB-94448

S-100 beta

Ms

9A11B9

IgG1

WB, IHC, ELISA

Aff. Pur.

Hu

100 ug

AB-83558

S-100 beta

Rb

POLY

IgG

WB,IHC(P) ,IF

Aff. Pur.

Hu, Ms, Rt

100μg

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