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Exosomes

Extracellular molecules, such as nucleotides, lipids, short peptides or proteins, are released by cells and bind to receptors on the other cells, which are important mediators in cell-to-cell communications in multicellular organisms. In addition to single molecules, eukaryotic cells can also release membrane vesicles into extracellular environment, such as microvesicles, apoptotic blebs and exosomes.

Exosomes represent a specific subtype of secreted membrane vesicles, showing a characteristic cup-shaped or well delimited round morphology when observed by electron microscopy. They are small membrane vesicles with a diameter of 30~100 nm. Derived from the endosomal compartments called multivesicular bodies (MVBs), exosomes contain diverse nucleic acids (mRNAs and miRNAs), lipids, peptides and proteins derived from the parent cells. Therefore, exosomes are thought to play an important role in intercellular communications, mediating numerous physiological processes (beyond immunology to neurobiology, stem cell and tumor biology) of the recipient cells. These features have prompted extensive research to exploit them as a source of biomarkers for several pathologies, such as inflammatory diseases, autoimmune disorders, neurodegenerative disorders and cancer.

The Exosomes Markers are: Alix Antibody, Calnexin Antibody, CD9 Antibody, CD24 Antibody, CD80 Antibody, CD81 Antibody, CD63/LAMP3 Antibody, LAMP1 Antibody, HSP70 Antibody, TSG101 Antibody

Cat. N.

Description

Host

Applications

Cross-Reactivity

Size

AB-83477

CD9

Rabbit

WB

Human,Mouse,Rat

100 ug

AB-84222

CD24

Rabbit

WB

Human

100 ug

AB-84221

CD80

Rabbit

WB, IF

Human, Mouse, Rat

100 ug

AB-83477 CD9 Polyclonal Antibody

Western blot analysis of extracts of

mouse kidney, using CD9 Antibody

at 1:1000 dilution.

AB-84222 CD24 Polyclonal Antibody Western blot analysis of extracts of Raji cells, using CD24 antibody at 1:1000 dilution.

AB-84221 CD80 Polyclonal Antibody Immunofluorescence analysis of Raw264.7 cells using CD80 antibody at dilution of 1:100.

Cat. N.

Description

Host

Applications

Cross-Reactivity

Size

AB-83878

CD81

Rabbit

WB,IHC

Mouse

100 ug

AB-83481

CD63/LAMP3

Rabbit

WB,IHC,IF

Human,Mouse,Rat

100 ug

AB-81337

LAMP1

Rabbit

WB,IHC(P), IF

Human, Mouse, Rat

100 ug

AB-83878 CD81 Polyclonal Antibody Immunohistochemistry of paraffin embedded mouse lung using CD81

antibody at dilution of 1:100

(40x lens).

AB-83481 CD63/LAMP3 Polyclonal Antibody

Western blot analysis of extracts of various cell lines, using CD63/LAMP3

Antibody at 1:1000 dilution.

AB-81337 LAMP1 Polyclonal Antibody

Western blot analysis of extracts of

various cell lines, using MCL1

antibody at 1:1000 dilution.

Cat. N.

Description

Host

Applications

Cross-Reactivity

Size

AB-84218

HSP70

Rabbit

WB,IHC,IF

Human,Mouse,Rat

100 ug

AB-84198

TSG101

Rabbit

WB,IP

Human,Mouse,Rat

100 ug

AB-84198 TSG101 Polyclonal Antibody

Western blot analysis of extracts of

various cell lines, using TSG101

antibody at 1:1000 dilution.

AB-84198 TSG101 Polyclonal Antibody

Immunohistochemistry of paraffin embedded Mouse kidney using TSG101 antibody at dilution

of 1:100 (40x lens).

AB-84198 TSG101 Polyclonal Antibody

Immunofluorescence analysis of L929

cells using TSG101 antibody at dilution of 1:100.

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