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EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer.

Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumors and improve the patient's condition.

Mutations that lead to EGFR overexpression (known as upregulation or amplification) have been associated with a number of cancers, including adenocarcinoma of the lung (40% of cases), anal cancers, glioblastoma (50%) and epithelial tumors of the head and neck (80-100%). These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division. In glioblastoma a specific mutation of EGFR, called EGFRvIII, is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers.

The EGFR Markers are: EGFR/HER1, HER2/ERBB2, HER3/ERBB3, HER4/ERBB4, Phospho-EGFR, Phospho-ErbB2/HER2, Phospho-ErbB3/HER3, Phospho-ErbB4/HER4.

Cat.

Antigen

Host

Clone

Isotype

Applications

Species

Q.ty

MAB-94443

EGFR / HER1

Ms

EGFR1

IgG1

WB, IF

Hu,

100 ug

MAB-90955

EGFR / HER1

Ms

EGFR1

IgG2b

FC, IP, IHC(F), ICC

Hu, Eq

100 ug

AB-81864

EGFR / HER1

Rb

POLY

IgG

WB, IHC(P), IF, IP

Hu, Ms, Rt

100 ug

AB-10103

EGFR / HER1

Rb

POLY

IgG

WB., IP, ELISA

Ms, Rt, Hu, Ha, Ch

100 ul

AB-84123

EGFR / HER1

Rb

POLY

IgG

WB, IHC(P), IF, EIA

Hu, Ms, Rt

100 ug

AB-81543

HER2 / ERBB2

Rb

POLY

IgG

WB, IHC(P)

Hu,Ms, Rt

100 ug

MAB-90157

HER2 / ERBB2

Ms

13H5-A8

IgG1

IHC(P), WB, IP

Hu, Ms

100 ul

AB-83503

HER3 / ERBB3

Rb

POLY

IgG

WB

Hu,Ms, Rt

100 ug

AB-81617

HER4 / ERBB4

Rb

POLY

IgG

WB, IHC

Ms, Rt

100 ug

ABP10348

Phospho-EGFR (S1026)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP-0153

Phospho-EGFR (S1070)

Rb

Poly

IgG

WB, IHC-p, ELISA

Hu, Ms, Rt

100 ug

ABP10350

Phospho-EGFR (S1071)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP10351

Phospho-EGFR (S695)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP-0301

Phospho-EGFR (T1068)

Rb

Poly

IgG

WB

Hu

100 ug

MAB-94208

Phospho-EGFR (T1068)

Rb

Poly

IgG

WB

Hu

100 ug

MAB-94205

Phospho-EGFR (T669)

Rb

D2F1

IgG

WB

Hu

100 ug

ABP-0025

Phospho-EGFR (T669)

Rb

Poly

IgG

WB

Hu

100 ug

ABP-0198

Phospho-EGFR (T678)

Rb

Poly

IgG

WB, IF, ELISA

Hu, Ms, Rt, Mk

100 ug

ABP-0199

Phospho-EGFR (T693)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

ABP10354

Phospho-EGFR (Y1016)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

MAB-94208

Phospho-EGFR (Y1068)

Rb

Poly

IgG

WB

H

100 ug

ABP-0301

Phospho-EGFR (Y1068)

Rb

Poly

IgG

WB

Hu

100 ug

ABP10355

Phospho-EGFR (Y1069)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt, Mk

100 ug

ABP-0636

Phospho-EGFR (Y1092)

Rb

Poly

IgG

WB, IHC-p, ELISA

Hu, Ms, Rt

100 ug

ABP-0243

Phospho-EGFR (Y1110)

Rb

Poly

IgG

WB

Hu

100 ug

ABP10357

Phospho-EGFR (Y1110)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP-0028

Phospho-EGFR (Y1148)

Rb

Poly

IgG

WB

Hu

100 ug

ABP-0218

Phospho-EGFR (Y1172)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

MAB-90138

Phospho-EGFR (Y1173)

Ms

EM-13

IgG1

FC, IP, WB

Hu

100 ug

ABP-0223

Phospho-EGFR (Y1197)

Rb

Poly

IgG

WB, IHC-p, ELISA

Hu, Ms, Rt

100 ug

MAB-94206

Phospho-EGFR (Y845)

Rb

D63B4

IgG

WB

Hu

100 ug

ABP-0023

Phospho-EGFR (Y845)

Rb

Poly

IgG

WB

Hu

100 ug

ABP-0224

Phospho-EGFR (Y869)

Rb

Poly

IgG

WB, IF, ELISA

Hu, Ms, Rt

100 ug

ABP-0026

Phospho-EGFR (Y992)

Rb

Poly

IgG

WB

Hu

100 ug

MAB-90139

Phospho-EGFR (Y992)

Ms

EM-12

IgG1

FC, WB, IP

Hu

100 ug

ABP-0024

Phospho-EGFR (Y998)

Rb

Poly

IgG

WB

Hu

100 ug

MAB-94207

Phospho-EGFR (Y998)

Rb

C24A5

IgG

WB

Hu

100 ug

ABP-0819

Phospho-EGFR-Y1045 pAb

Rb

Poly

IgG

WB

Human

100 ug

ABP-0820

Phospho-EGFR-Y1086 pAb

Rb

Poly

IgG

WB

Human

100 ug

ABP-0527

Phospho-ErbB2/HER2-(Y1221/1222)

Rb

Poly

IgG

WB

Hu

100 ug

MAB-94209

Phospho-ErbB2/HER2-(Y1221/1222)

Rb

6B12

IgG

WB

Hu

100 ug

ABP-0152

Phospho-ErbB2/HER2-(Y1248)

Rb

Poly

IgG

WB, IHC, ELISA

Hu

100 ug

ABP-0148

Phospho-ErbB2/HER2-(Y877)

Rb

Poly

IgG

WB

Hu

100 ug

ABP10385

Phospho-ErbB3/HER3 (Y1222)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

ABP10387

Phospho-ErbB3/HER3 (Y1328)

Rb

Poly

IgG

IHC-p, ELISA

Hu, Ms, Rt

100 ug

MAB-94210

Phospho-ErbB3/HER3 (Y1328)

Rb

E1J1T

IgG

IHC-p, ELISA

Hu, Ms, Rt

100 ug

ABP10384

Phospho-ErbB3/HER3 (Y1197)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP10386

Phospho-ErbB3/HER3 (Y1289)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

MAB-94267

Phospho-ErbB3/HER3 (Y1289)

Rb

D1B5

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

ABP-0277

Phospho-ErbB3/HER3 (Y1328)

Rb

Poly

IgG

WB, IHC, IF

Hu, Ms, Rt

100 ug

ABP-0034

Phospho-ErbB4/HER4 (Y1284)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

MAB-94211

Phospho-ErbB4/HER4 (Y1284)

Rb

21A9

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

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