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MET

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.

MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the MET receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF/SF is restricted to cells of mesenchymal origin. When HGF/SF binds its cognate receptor MET it induces its dimerization through a not yet completely understood mechanism leading to its activation.

Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body. Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.

Various mutations in the MET gene are associated with papillary renal carcinoma.

The MET Markers are: c-Met, Phospho-Met.

Cat.

Antigen

Host

Clone

Isotype

Applications

Species

Q.ty

AB-82708

MET (c-Met)

Rb

POLY

IgG

WB

Hu,Ms,Rt

100μg

AB-83944

MET (c-Met)

Rb

POLY

IgG

WB

Hu,Ms,Rt

100μg

MAB-94442

MET (c-Met)

Ms

MET24

IgG

WB, IHC, IF

Hu

100μg

AB-84121

MET (c-Met)

Rb

POLY

IgG

WB, IF, EIA

Hu,Ms,Rt

100μg

ABP-0076

Phospho-Met (Y1003)

Rb

Poly

IgG

WB, IHC-p, IF, ELISA

Hu, Ms, Rt

100 ug

ABP-0078

Phospho-Met (Y1234)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt, Mk

100 ug

ABP-0408

Phospho-Met (Y1234/Y1235)

Rb

Poly

IgG

WB

Hu, Ms, Rt

100 ug

MAB-3305

Phospho-Met (Y1234/Y1235)

Rb

3D7

IgG

WB

Hu, Ms, Rt

100 ug

ABP-0079

Phospho-Met (Y1235)

Rb

Poly

IgG

WB, IF

Hu, Ms, Rt

100 ug

MAB-97000

Phospho-Met (Y1235)

Rb

13D11

IgG

WB, IF

Hu, Ms, Rt

100 ug

ABP-0077

Phospho-Met (Y1349)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

MAB-53309

Phospho-Met (Y1349)

Rb

13DH2

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

ABP11206

Phospho-Met (Y1349)

Rb

Poly

IgG

WB, IHC, IF

Hu

100 ug

ABP11207

Phospho-Met (Y1356)

Rb

Poly

IgG

WB, ELISA

Hu, Ms, Rt

100 ug

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